Hematopoietic Development and Disease

Scadden Laboratory

The Scadden lab focuses on blood, particularly the regulation of the hematopoietic stem cell by its microenvironment or niche. Using a combination of genetically modified mice, imaging and pharmacology, the laboratory has defined key components of the niche and how stem cells traffic to and engraft the bone marrow. It has demonstrated methods of altering niche interactions that have resulted in two clinical trials in the use of stem cells to treat hematologic malignancies.

Zon Laboratory

Dr. Leonard Zon's laboratory focuses on the developmental biology of hematopoiesis and cancer. Over the past five years, we have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. For instance, the isolation of the ferroportin iron transporter was based on a mutant zebrafish and subsequently was shown to be mutated in patients with iron overload disorders. The mutants also represent interesting key regulatory steps in the development of stem cells. Recently, a mutant was found that lacked blood stem cells...

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Wagers Laboratory

Effective functioning of the body’s tissues and organs depends upon innate regenerative processes that maintain proper cell numbers (homeostasis) and replace damaged cells after injury (repair).  In many tissues, regenerative potential is determined by the presence and functionality of a dedicated population of stem and progenitor cells, which respond to exogenous cues to produce replacement cells when needed.  Understanding how these unspecialized precursors are maintained and regulated is essential for understanding the fundamental biology of tissues.  In addition, this...

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