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Buenrostro Lab

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Principal Investigator

Jason Buenrostro, Ph.D.

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The Buenrostro lab is broadly dedicated to advancing our knowledge of gene regulation and the downstream consequences on cell fate decisions. To do this, the Buenrostro lab develops new technologies utilizing molecular biology, microscopy and bioinformatics approaches and applies these tools to study stem cells in normal, ageing and cancer tissues in effort to discover chromatin regulators and their contribution to disease.

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Contact Information
Bauer building, 2nd Floor, 7 Divinity Ave., Cambridge, MA 02138
Faculty Profile
Image of Jason Buenrostro, Ph.D.

Jason Buenrostro, Ph.D.

  • Alvin and Esta Star Associate Professor of Stem Cell and Regenerative Biology
  • Associate Member
    Broad Institute of Harvard and MIT

Jason Buenrostro is the Alvin and Esta Star Associate Professor of Stem Cell and Regenerative Biology. In previous work, Dr. Buenrostro developed the ATAC-seq and single-cell ATAC-seq methods, which enable measurements of chromatin regulation at single-cell resolution. At Harvard University, the Buenrostro lab is broadly dedicated to advancing our knowledge of gene regulation and the downstream consequences on cell fate decisions. To do this, the Buenrostro lab develops new technologies employing approaches across molecular biology, microscopy and bioinformatics. Further, the Buenrostro lab applies these tools to study stem cells in normal, ageing and cancer tissues in effort to discover regulators of chromatin structure and their contribution to disease. Dr. Buenrostro earned a BS in General Engineering and a BS in Biology at Santa Clara University. He did his doctoral work with William Greenleaf and Howard Chang at Stanford University in the Department of Genetics.

Featured Publications

  • Papathanasiou S, Mynhier NA, Liu S, Brunette G, Stokasimov E, Jacob E, Li L, Comenho C, van Steensel B, Buenrostro JD, Zhang CZ, Pellman D. 2023. Heritable transcriptional defects from aberrations of nuclear architecture. Nature. 619(7968):184-192. Pubmed: 37286600 DOI:10.1038/s41586-023-06157-7
    Read Abstract
  • Cheong JG, Ravishankar A, Sharma S, Parkhurst CN, Grassmann SA, Wingert CK, Laurent P, Ma S, Paddock L, Miranda IC, Karakaslar EO, Nehar-Belaid D, Thibodeau A, Bale MJ, Kartha VK, Yee JK, Mays MY, Jiang C, Daman AW, Martinez de Paz A, Ahimovic D, Ramos V, Lercher A, Nielsen E, Alvarez-Mulett S, Zheng L, Earl A, Yallowitz A, Robbins L, LaFond E, Weidman KL, Racine-Brzostek S, Yang HS, Price DR, Leyre L, Rendeiro AF, Ravichandran H, Kim J, Borczuk AC, Rice CM, Jones RB, Schenck EJ, Kaner RJ, Chadburn A, Zhao Z, Pascual V, Elemento O, Schwartz RE, Buenrostro JD, Niec RE, Barrat FJ, Lief L, Sun JC, Ucar D, Josefowicz SZ. 2023. Epigenetic memory of coronavirus infection in innate immune cells and their progenitors. Cell. 186(18):3882-3902.e24. Pubmed: 37597510 DOI:S0092-8674(23)00796-1
    Read Abstract
  • Mangiameli SM, Chen H, Earl AS, Dobkin JA, Lesman D, Buenrostro JD, Chen F. 2023. Photoselective sequencing: microscopically guided genomic measurements with subcellular resolution. Nature methods. 20(5):686-694. Pubmed: 37106232 DOI:10.1038/s41592-023-01845-8
    Read Abstract
  • Joung J, Ma S, Tay T, Geiger-Schuller KR, Kirchgatterer PC, Verdine VK, Guo B, Arias-Garcia MA, Allen WE, Singh A, Kuksenko O, Abudayyeh OO, Gootenberg JS, Fu Z, Macrae RK, Buenrostro JD, Regev A, Zhang F. 2023. A transcription factor atlas of directed differentiation. Cell. 186(1):209-229.e26. Pubmed: 36608654 DOI:S0092-8674(22)01470-2
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  • Kartha VK, Duarte FM, Hu Y, Ma S, Chew JG, Lareau CA, Earl A, Burkett ZD, Kohlway AS, Lebofsky R, Buenrostro JD. 2022. Functional inference of gene regulation using single-cell multi-omics. Cell genomics. 2(9). Pubmed: 36204155 DOI:10.1016/j.xgen.2022.100166
    Read Abstract
  • Ana Uzquiano, Amanda J Kedaigle, Martina Pigoni, Bruna Paulsen, Xian Adiconis, Kwanho Kim, Tyler Faits, Surya Nagaraja, Noelia Antón-Bolaños, Chiara Gerhardinger, Ashley Tucewicz, Evan Murray, Xin Jin, Jason Buenrostro, Fei Chen, Silvia Velasco, Aviv Regev, Joshua Z Levin, Paola Arlotta. 2022. Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex. Cell. 185(20):3770-3788.e27. DOI:10.1016/j.cell.2022.09.010
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