Nuclear Reprogramming

Eggan Laboratory

Our research is focused on understanding the contribution of environmental and genetic factors in the development of disease. The relative impact of these factors to pathogenesis is not well understood for many disorders. Complex interactions between genes and the environment have made it particularly difficult to develop accurate models for the sporadic and so called multifactorial forms of human disease.

Meissner Laboratory

Our laboratory is a mixed group of experimental and computational biologists in the Department of Stem Cell and Regenerative Biology (HSCRB).  We use genomic tools to study developmental and stem cell biology with a particular interest in the role of epigenetic regulation (Mikkelsen et al. Nature 2008; Koche, Smith et al. Cell Stem Cell 2011).

The term epigenetic refers to stable modifications of the chromatin and DNA that do not alter the primary nucleotide sequence. The global epigenetic makeup of a cell is a powerful indicator of its developmental state and potential. We...

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Melton Laboratory

We study the developmental biology of the pancreas with a view to finding new treatments for diabetes. Our aim is to understand how the pancreas develops and use that information to grow and develop new pancreatic cells (Islets of Langerhans). This project is an example of the larger question of how vertebrates make an organ from undifferentiated embryonic cells.

Our experimental approaches use the tools of molecular, cellular and chemical biology to investigate how precursor or stem cells give rise to the pancreas and how pancreatic tissue is maintained in adults.   This...

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Hochedlinger Laboratory

Our lab tries to understand the molecular mechanisms underlying pluripotency and nuclear reprogramming. Pluripotency denotes the ability of cells, such as embryonic stem (ES) cells, to give rise to all cell types of the mammalian body, while nuclear reprogramming is the dedifferentiation of a specialized cell back into a pluripotent state. Reprogramming does not normally occur in vivo but can be achieved experimentally by nuclear transfer, ES cell-somatic cell fusion and by directly inducing embryonic genes in somatic cells, generating so-called induced pluripotent (iPS) stem cells.