Jeffrey Macklis investigates molecular controls and mechanisms over neuron subtype specification, development, diversity, axon guidance-circuit formation, and pathology in the cerebral cortex. His lab seeks to apply developmental controls toward brain and spinal cord regeneration and directed differentiation for in vitro mechanistic modeling using human assembloids.
I am interested in understanding the molecular and cellular mechanisms underlying the establishment of callosal projection neuron (CPN) circuitry, and the role of CPN in disease-relevant social and cognitive behavior.
I am interested in the assembly and function of neuronal circuits during human cortical development, and I am especially interested in the molecular mechanisms that determine neuronal identity and function.
By applying my skills and previous experiences in cellular and development neurobiology, I aim to contribute towards research in sub-type neuronal development and specification and regenerative spinal cord injury modeling.
I am interested in cellular repair of upper motor neuron circuitry diseased in ALS and spinal cord injury. Besides, I investigate the development, connectivity, and diversity of corticostriatal neurons.