Our goal is to understand heart failure and metabolic diseases that accompany human aging, as these diseases are now major barriers to healthy aging. We are interested in translating that understanding into therapies, including stem cell transplantation strategies and new biological agents.
Our approach is to understand human problems and design solutions in the laboratory, and then we demonstrate the effectiveness of these solutions in vivo. Ongoing projects in the laboratory include studies of cardiac regeneration, diabetes, aging, and metabolism.
Glucose: From Molecule to Society
We will explore the biochemistry, cell biology, and physiology that make glucose our main source of energy. How did humans depend on and crave this molecule? What consequences does it hold for normal metabolism and disease? Students will integrate evolution, endocrinology, biostatistics, bioengineering, and regenerative biology approaches in considering sugar and all its consequences. Finally, we will evaluate legal and business issues necessary to move scientific and technical innovations from the laboratory to the patient.