| Our Faculty

Wagers Lab

Amy Wagers lab at the HSCRB annual retreat, Boston Museum of Science 2018. Photo by Lisa Fountain

Our Research

Our research focuses on uncovering the intrinsic and extrinsic regulators of stem cell function, and revealing how changes in stem cell activity impact tissue regeneration throughout life.

We exploit novel systems developed in our laboratory to uncover the cellular and molecular processes that underlie the stem cell dysfunction that typically arises with advancing age, and that can promote tumor development.

Exciting new data from our studies suggests that stem cell aging is controlled at least in part by blood-borne mediators, which change with age and can be manipulated to reverse age-associated dysfunction.

Our future work will use the new insights gained from these studies to enable novel interventions to delay or reverse the onset of age-related disease and extend the healthful life of aging individuals.

Areas of Investigation

Before and After image of cells

Editing stem cells in vivo

Building on our work in mice with Duchenne muscular dystrophy, our group used an adeno-associated virus (AAV) as a transport vehicle to deliver gene-editing cargo rapidly into several different types of skin, blood, and muscle stem and progenitor cells. We are expanding this work, which has implications for the development of therapies for diseases like spinal muscular atrophy.

Novel regulators of stem cell trafficking

Our studies have identified novel regulators of stem cell trafficking, including the transcription factor EGR1, which uniquely co-ordinates the migration and proliferation of blood stem cells in order to maintain appropriate stem cell number in the bone marrow and to support peripheral immune and inflammatory responses.

Marker-based cell sorting to analyze precursor cells

We developed and applied marker-based cell sorting approaches to analyze precursor cells in skeletal muscle, and identified a subset of satellite cells (mononuclear cells found beneath the basal lamina surrounding mature muscle fibers) that act as muscle stem cells. We demonstrated that these unique stem cells exhibit robust self-renewal and myogenic differentiation activity, and can restore muscle function when transplanted into injured or diseased muscle.

Join Our Lab

Our lab welcomes applications from postdoctoral fellows. Candidates should send their research statement, CV, and referee list to Amy Wagers.
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