Rubin Lab July 2023
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Rubin Lab

Rubin Lab People

Photo of Lee Rubin

Lee Rubin investigates the key molecular mediators of a variety of neurodegenerative diseases, with the ultimate goal of finding effective preclinical therapeutic candidates.

Photo of Jane LaLonde

Jane is the Rubin Lab Administrator, providing logistical and organizational support to Lee Rubin and members of the laboratory. Jane earned a B.S in Social Work at Syracuse University, and a B.F.A at Massachusetts College of Art and Design (MassArt).

Research Scientists

Photo of Feodor Price

Feo’s research is translational in nature and geared towards studying how adult skeletal muscle stem cells are involved in regulating muscle regeneration.

Postdoctoral Fellows

Photo of Caterina Gasperini

Caterina is studying mechanisms of brain aging primarily using aged mouse models. Her work focuses on understanding how different manipulations such as heterochronic parabiosis, GDF11 administration and gut microbiome depletion can counteract the aging process. The aim of her research is to identify candidates that could be targets for clinical applications in humans.

Photo of Richard Giadone

Rich uses human iPSCs and mouse models to understand and manipulate proteostasis in disease and aging.

Photo of Junghyun Lee

Junghyun is studying the pathways regulating blood-brain barrier during development and aging. His work is focused on developing in vitro model of brain endothelial cells using human iPSCs.

Photo of Kaylee Wells

Kaylee is investigating the mechanism of brain aging. Through transgenic and aged mouse models, she is studying the function of a protein, GDF11 within the brain. The aim of her research is to provide a molecular understanding of GDF11’s function and better inform its potential as a therapeutic.

Graduate Students

Photo of Kelsey Goune

Research Scholar, Graduate School of Arts and Sciences

Research Assistants

Photo of Jiye Lee

Jiye is working on developing an in vitro model of the blood-brain barrier to study the effects of endogenous or systemically injected aging related factors on the brain using iPSCs.

Undergraduate Research Students

Photo of Cristina DeMeo

Class of 2025

Photo of Sayalee Patankar

Class of 2025

Photo of Alvira Tyagi

Class of 2025. Alvira is studying the link between the protein GDF11 and myelination-related signaling and pathways, with a particular focus on how GDF11 influences myelin stability and structure. Based on her results, she aims to understand if GDF11 could serve as a clinical therapeutic target for demyelinating and aging-related diseases.

Photo of Victoria Wong

Class of 2024. Victoria is studying the different roles of the MAFF transcription factor in young versus old brain endothelial cells.

Photo of Cerena Wu

Class of 2025

Photo of Nicole Zuno

Class of 2025

Recent Alumni

Photo of Francesco Limone

Francesco is a visiting PhD student at HSCRB and the Stanley Center at Broad Institute. His work focuses on the understanding of molecular mechanisms underlying neuroinflammation, neurological disorders and aging using human iPSC-derived neuronal cells, mouse models, and computational approaches.

Photo of Richard Krolewski

Rich is a movement disorders neurologist using dopamine neurons made from the iPSCs of Parkinson’s Disease patients to better understand how gene/environment interactions influence disease pathogenesis and inform new treatment options.

Photo of Ioannis Gampierakis

Postdoctoral Fellow

Photo of Francesca Rapino

Postdoctoral Fellow Francesca is a postdoctoral fellow at HSCRB and at the Broad Institute. Her work seeks to understand the role of complement component in schizophrenia, using iPSC derived neuronal cultures and small molecule screening.

Photo of Xiaoyu Hu

Postdoctoral Fellow

Photo of Ceren Ozek

Ceren is a postdoctoral fellow studying the beneficial vascular and neural effects of GDF11 on healthy aging and neurodegenerative diseases, specifically Alzheimer’s Disease, using transgenic mice as model organisms.

Photo of Chen Wu

Postdoctoral Fellow Chen Wu is looking for a novel and specific drug to improve the survival of motor neurons for ALS therapeutics. By studying the targets of the drug, he hopes to explain the mechanism and how the downstream signal pathways work.

Photo of Brittany Mayweather

Graduate Student Brittany’s research investigates the physiological role of endogenous GDF11 during adult neurogenesis and the therapeutic implications of manipulating GDF11 signaling.

Photo of Michelle Watts

Graduate Student Michelle is a senior graduate student in Harvard’s Biological and Biomedical Sciences program. Her research focuses on developing predictive models of ALS using patient cells to investigate convergent protective mechanisms behind therapeutic compounds.

Photo of Sabrina Ghosh

Sabrina is studying protein quality control machinery in the aging brain using human iPSC-derived and in vivo mouse models.

Photo of Rio McLellan

Class of 2023

Photo of Kavya Shah

Class of 2023. Kavya is studying the role of KLF6 in the aging of the blood-brain barrier.

Photo of Methodios Ximerakis

Methodios is looking to identify cellular and molecular mechanisms that trigger brain aging and rejuvenation by using single-cell transcriptomics.

Photo of Hye Young Shin

Hye Young Shin studies early changes during human motor neuron degeneration, using automated live cell imaging. She also uses long-term, live imaging of motor neurons differentiated from hESCs and iPSCs for survival assay development and its application in drug screening.

Photo of Scott Logan Lipnick

Scott Lipnick is a principal scientist in the Rubin Lab and an Instructor in Biomedical Informatics at Harvard Medical School. He is also a member of the Massachusetts General Hospital Center for Assessment Technology and Continuous Health (CATCH).

Photo of Gizem Rizki

Gizem is a research scientist who specializes in assay development and high-throughput screening and runs the screening operations in the lab. She collaborates with screeners to set up and execute small molecule screens to identify therapeutic targets of neurodegenerative, neuropsychiatric, and other diseases as well as unravel biological insights into disease mechanisms through screening.

Photo of Kathleen Pfaff

Kathy is the Senior Research Manager in the Rubin Laboratory. She advises individuals and teams on their research projects, serves as the liaison between the lab and external collaborators, and provides operational and financial oversight.

Join Our Lab

We are always seeking highly motivated students and postdoctoral fellows who are passionate about understanding the biological basis of neurological disease. Postdoctoral candidates are welcome to send a research statement and CV to Lee Rubin.
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