Rich Lee seeks to understand heart failure and metabolic diseases that accompany human aging, and translate that understanding into therapies. Lee is an active clinician, regularly treating patients at Brigham and Women’s Hospital.
Alexander is focused on identifying the causal role of mitochondrial DNA mutations in aging and cardiovascular disease, as well as the development of therapeutic interventions to restore or improve mitochondrial function and disease outcomes.
Yijun is a G3 graduate student in the Lee Lab. She studies identified and novel DNA adducts in mammalian cells by defining their structure, formation, and repair mechanisms.
Darcie is focused on understanding the effects of mitochondrial DNA mutations on aging and cardiovascular diseases as well as developing therapeutic interventions to improve disease outcomes.
Kolia is investigating the distribution and functional impact of MELAS mutation (m.3243A>G) heteroplasmy in cardiomyocytes and developing novel mitochondrial gene editing strategies to restore dysfunction.
Ellie is working on understanding the effects of mitochondrial disease on cell diversity and cell fate and on developing therapeutic interventions to prevent these adverse effects.
