Camargo Lab Research
The Camargo laboratory focuses on the study of adult stem cell biology, organ size regulation, and cancer.
Despite fantastic progress in developmental biology research over the past decade, one aspect of development and tissue homeostasis for which very little is understood is how individual tissues reach and then maintain their appropriate size. Classic studies have demonstrated that tissues are able to ‘sense’ their size and expand or shrink until a correct dimension has been reached. Nevertheless, the nature of the molecules and pathways involved in this process remain mysterious.
Areas of Investigation
Organ Size Regulation
How do individual tissues reach and then maintain their appropriate size? Our laboratory utilizes a variety of genetic, biochemical, and high throughput technologies to identify molecules and mechanisms that regulate this fascinating process in mammals.
Characterization of Hematopoietic Stem Cells In Vivo
We study the roles of transcription factors and microRNAs in stem cell fate decisions, differentiation, and malignancy within living systems. Our novel methodology makes it possible to track and monitor individual hematopoietic stem cells and their progeny, and we are expanding this into an experimental paradigm to study complex populations of stem cells in situ.