Kelly OG, Melton DA. 1995. Induction and patterning of the vertebrate nervous system. Trends in genetics : TIG. 11(7):273-8. Pubmed: 7482777


The formation of the vertebrate central nervous system depends on a series of inductive interactions. Ventral ectoderm gives rise to epidermis (skin), whereas dorsal ectoderm forms neurectoderm, which is regionalized along the anteroposterior axis in response to inductive signals from dorsal mesoderm. Specific neural cell types are established along the dorsoventral axis of the neural tube by inductive signals from the dorsal mesoderm and prospective epidermis. We review the induction and patterning of the nervous system, with an emphasis on molecules that might play a role in these interactions.

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Doug Melton is pursuing a cure for type 1 diabetes. His lab studies the developmental biology of the pancreas, using that information to grow and develop pancreatic cells (islets of Langerhans). In parallel, they investigate ways to protect beta cells from autoimmune attack.

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