(2018) Stem cell reports: What's in a (Sub)strain?

Citation

Goldstein JM, Wagers AJ. 2018. What's in a (Sub)strain?. Stem cell reports. 11(2):303-305. Pubmed: 30110622 DOI:S2213-6711(18)30316-3

Abstract

C57BL/6J and C57BL/6N inbred mice are widely, and often interchangeably, used for stem cell research; yet, these substrains harbor discrete genetic differences that can cause phenotypic disparities. In this issue of Stem Cell Reports, Morales-Hernández et al. identify one particular difference-disruption of Nicotinamide Nucleotide Transhydrogenase (Nnt)-that increases reactive oxygen exposure and impairs hematopoietic progenitor cell function in C57BL/6J, as compared to C57BL/6N, mice.

Related Faculty

Amy Wagers, Ph.D.

Wagers Lab

Amy Wagers seeks to change the way we repair our tissues after an injury. Her research focuses on defining the factors and mechanisms that regulate the migration, expansion, and regenerative potential of adult blood-forming and muscle-forming stem cells.