The molecular signals that regulate the regenerative function of satellite cells in the skeletal muscle remain largely obscure. In this issue of Cell Stem Cell, Brack et al. (2008) report that direct molecular crosstalk between stem cell self-renewal and differentiation pathways determines the timing and efficiency of muscle repair.

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Amy Wagers seeks to change the way we repair our tissues after an injury. Her research focuses on defining the factors and mechanisms that regulate the migration, expansion, and regenerative potential of adult blood-forming and muscle-forming stem cells.

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