(2002) Gene therapy: Cell fate determination from stem cells

Citation

Wagers AJ, Christensen JL, Weissman IL. 2002. Cell fate determination from stem cells. Gene therapy. 9(10):606-12. Pubmed: 12032706

Abstract

In the adult, tissue-specific stem cells are thought to be responsible for the replacement of differentiated cells within continuously regenerating tissues, such as the liver, skin, and blood system. In this review, we will consider the factors that influence stem cell fate, taking as a primary example the cell fate determination of hematopoietic stem cells.

Related Faculty

Amy Wagers, Ph.D.

Wagers Lab

Amy Wagers seeks to change the way we repair our tissues after an injury. Her research focuses on defining the factors and mechanisms that regulate the migration, expansion, and regenerative potential of adult blood-forming and muscle-forming stem cells.