| People

Xiao Han, Ph.D.

I am a postdoc skilled in molecular and cell biology and dedicated to stem cell therapy and gene therapy. Since 2018 when I joined the Melton lab, I have been working on tackling the immune barrier in allogeneic beta-cell transplantation. Previously, I worked as a postdoc in Chad Cowan’s lab from 2015 to 2018, where I employed gene editing tools to generate hypoimmunogenic human pluripotent stem cells by knocking out HLA molecules and knocking-in the immunomodulatory factors. To test the immunogenicity of our products, I developed and conducted multiple in vitro and in vivo immunoassays. I obtained my PhD from Peking University in 2014. During my PhD training in Yongfeng Shang’s lab, I studied on epigenetic mechanisms in neural differentiation and breast cancer. I acquired my Bachelor of Science from Peking University in 2009.


Xiao Han, Mengning Wang, Songwei Duan, Paul J. Franco, Jennifer Hyoje-Ryu Kenty, Preston Hedrick, Yulei Xia, Alana Allen, Leonardo M. R. Ferreira, Jack L. Strominger, Douglas A. Melton, Torsten B. Meissner, and Chad A. Cowan. Generation of hypoimmunogenic human pluripotent stem cells. Proceedings of the National Academy of Sciences. 2019; 116 (21): 10441-10446.

Wanjin Li, Zihan Zhang, Xinhua Liu, Xiao Cheng, Yi Zhang, Xiao Han, Yu Zhang, Shumeng Liu, Jianguo Yang, Bosen Xu, Lin He, Luyang Sun, Jing Liang, and Yongfeng Shang. The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer. The Journal of Clinical Investigation. 2017, 127(9): 3421–3440.

Wenzhe Si, Wei Huang, Yu Zheng, Yang Yang, Xujun Liu, Ruorong Yan, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Jie Gao, Ruorong Yan, Xiao Han, Wanjin Li, Lin He, Lei Shi, Chenghao Xuan, Jing Liang, Luyang Sun, Yan Wang, and Yongfeng Shang. Dysfunction of the reciprocal feedback loop between GATA3- and ZEB2-nucleated repression programs contributes to breast cancer metastasis. Cancer Cell. 2015, 27(6): 822-836.

Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li, Peiyan Wang, Liandi Lei, Hongquan Zhang, Fei Pei, Dengfeng Cao, Luyang Sun, and Yongfeng Shang. SCFJFK is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes & Development. 2015, 29(6): 672-685.

Xiaohan Yang, Jianguo Yang, Lei Li, Luyang Sun, Xia Yi, Xiao Han, Wenzhe Si, Ruorong Yan, Zhe Chen, Guojia Xie, Wanjin Li, Yongfeng Shang, and Jing Liang. PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis. FASEB Journal. 2014, 28(11): 4821-4834.

Xiao Han, Bin Gui, Cong Xiong, Linnan Zhao, Jing Liang, Luyang Sun, Xiaohan Yang, Wenhua Yu, Wenzhe Si, Ruorong Yan, Xia Yi, Di Zhang, Wanjin Li, Lifang Li, Jianguo Yang, Yan Wang, Yi Eve Sun, Dai Zhang, Anming Meng, and Yongfeng Shang. Destabilizing LSD1 by Jade-2 promotes neurogenesis: an anti-braking system in neural development. Molecular Cell. 2014, 55 (3): 482-494.

Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun, and Yongfeng Shang. JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. PLoS Biology. 2014, 12(3): e1001819.

Na Yu, Peiwei Huangyang, Xiaohan Yang, Xiao Han, Ruorong Yan, Hongti Jia, and Yongfeng Shang, Luyang Sun. MicroRNA-7 suppresses the invasive potential of breast cancer cells and sensitizes cells to DNA damages by targeting histone methyltransferase SET8. The Journal of Biological Chemistry. 2013, 288 (27): 19633-19642.

Xiaohan Yang, Lei Li, Jing Liang, Lei Shi, Jianguo Yang, Xia Yi, Di Zhang, Xiao Han, Na Yu, and Yongfeng Shang. Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover. The Journal of Biological Chemistry. 2013, 288 (25): 18271-18282.

Chenghao Xuan, Qian Wang, Xiao Han, Yang Duan, Lei Li, Lei Shi, Yan Wang, Lin Shan, Zhi Yao, and Yongfeng Shang. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. 2013, 32: 3711–3721

Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang, Chenghao Xuan, Zhipeng Yu, and Yongfeng Shang. Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 2012, 44(6): 886-895.

Fen Yang, Luyang Sun, Qian Li, Xiao Han, Liandi Lei, Hua Zhang, and Yongfeng Shang. SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities. The EMBO Journal. 2012, 31 (1): 110-123.

Xiaohan Yang, Wenhua Yu, Lei Shi, Luyang Sun, Jing Liang, Xia Yi, Qian Li, Yu Zhang, Fen Yang, Xiao Han, Di Zhang, Jie Yang, Zhi Yao, and Yongfeng Shang. HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Molecular Cell. 2011, 44 (1): 39-50.

Qian Li, Lei Shi, Bin Gui, Wenhua Yu, Jiamu Wang, Di Zhang, Xiao Han, Zhi Yao, and Yongfeng Shang. Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. Cancer Research. 2011, 71 (21): 6899-6908.

Lei Shi, Luyang Sun, Qian Li, Jing Liang, Wenhua Yu, Xia Yi, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang, Chenghao Xuan, Zhi Yao, and Yongfeng Shang. Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proceedings of the National Academy of Sciences. 2011, 108 (18): 7541-7546.

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