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Özge Vargel Bölükbaşı, Ph.D.

Ozge is interested in understanding the molecular mechanism of hematopoietic stem cell (HSC) function. She did her Ph.D. at EMBL (Italy) and Heidelberg University on the mechanism of how first HSCs in the mouse embryo emerge. Afterward, she worked on human HSCs and patient-derived induced pluripotent stem cells to understand the underlying mechanism of hematological diseases. Currently, in Wagers lab, her postdoctoral project is on the regulation of HSC expansion, self-renewal, and differentiation in the adult mouse. The methods she employs include stem cells (mouse ESC, human iPSC, HSPC), single-cell transcriptomics, real-time polymerase chain reaction (qRT-PCR), lentivirus production, lentiviral-based gene expression and gene knock-down.

Özge obtained her Ph.D. from Heidelberg University and the European Molecular Biology Laboratory (EMBL). Her doctoral work focused on mouse developmental hematopoiesis.

Selected publications

Joyce CE, Saadatpour A, Ruiz-Gutierrez M, Bolukbasi OV, Jiang L, Thomas DD, Young S, Hofmann I, Sieff C, Myers KC, Whangbo J, Libermann TA, Nusbaum C, Yuan GC, Shimamura A, Novina CD. (2019) TGFβ signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond Syndrome. J Clin Invest. 130; doi:10.1172/jci125375

Ruiz-Gutierrez M, Bölükbaşı ÖV, Alexe G, Kotini AG, Ballotti K, Joyce CE, Russell DW, Stegmaier K, Myers K, Novina CD, Papapetrou EP, Shimamura A. (2019) Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells. JCI Insight. 5; doi:10.1172/jci.insight.125157

Bergiers I, Tischer C, Vargel Bölükbaşı Ö, Lancrin C. (2019) Quantification of Mouse Hematopoietic Progenitors’ Formation Using Time-lapse Microscopy and Image Analysis. Bio Protoc. 9; doi:10.21769/BioProtoc.3137

Bergiers I, Andrews T, Vargel Bölükbaşı Ö, Buness A, Janosz E, Lopez-Anguita N, Ganter K, Kosim K, Celen C, Itır Perçin G, Collier P, Baying B, Benes V, Hemberg M, Lancrin C. (2018) Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis. Elife. 7; doi:10.7554/eLife.29312

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