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Elad Sintov, Ph.D.

Elad studied biotechnology engineering for his BSc in Ben-Gurion University, Israel and continued with an immunology research on the interleukin-1 alpha intracellular function during his MSc studies. After some years in the biotech industry, he started his PhD studying adult human beta-cell-derived cell redifferentiation after expansion ex-vivo. Elad is a post-doctoral fellow in the lab since 2016 and is working on ways to model autoimmunity in vitro, generate “immuno-transparent” beta-cells for transplantations and to gain new insights that could allow for preventing/blocking the autoimmune response in type-1 diabetes.



Veres A, Faust AL, Bushnell HL, Engquist EN, Kenty JH, Harb G, Poh Y, Sintov E, Gürtler M, Pagliuca FW, Peterson QP, Melton DA. Charting cellular identity during in vitro differentiation of human pancreatic beta cells. Nature. 569(7756), 368-373 (2019)

Sintov E, Nathan G, Knoller S, Russ HA, Efrat S. Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro. Sci. Rep. 5, 13024; doi: 10.1038/srep13024 (2015).

Russ HA, Sintov E, Anker-Kitai L, Friedman O, Lenz A, Toren G, Farhy C, Oron-Karni V, Ravassard P, and Efrat S, Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS One. 6(9): p. e25566. (2011)

Bar Y, Russ HA, Sintov E, Anker-Kitai L, Knoller S, and Efrat S, Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway. J Biol Chem. 287(21): p. 17269-80. (2012)

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