Directed Differentiation

Eggan Laboratory

Our research is focused on understanding the contribution of environmental and genetic factors in the development of disease. The relative impact of these factors to pathogenesis is not well understood for many disorders. Complex interactions between genes and the environment have made it particularly difficult to develop accurate models for the sporadic and so called multifactorial forms of human disease.

Meissner Laboratory

Our laboratory is a mixed group of experimental and computational biologists in the Department of Stem Cell and Regenerative Biology (HSCRB).  We use genomic tools to study developmental and stem cell biology with a particular interest in the role of epigenetic regulation (Mikkelsen et al. Nature 2008; Koche, Smith et al. Cell Stem Cell 2011).

The term epigenetic refers to stable modifications of the chromatin and DNA that do not alter the primary nucleotide sequence. The global epigenetic makeup of a cell is a powerful indicator of its developmental state and potential. We...

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Melton Laboratory

We study the developmental biology of the pancreas with a view to finding new treatments for diabetes. Our aim is to understand how the pancreas develops and use that information to grow and develop new pancreatic cells (Islets of Langerhans). This project is an example of the larger question of how vertebrates make an organ from undifferentiated embryonic cells.

Our experimental approaches use the tools of molecular, cellular and chemical biology to investigate how precursor or stem cells give rise to the pancreas and how pancreatic tissue is maintained in adults.   This...

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Rubin Laboratory

Our laboratory focuses on translational, high-throughput research to model disease and develop drugs using stem cells. We have established an extensive range of complex image based assays that have been used to probe various properties of stem cells and of many cells derived from them. To accomplish this we use automated high content screening imagers, associated robotic equipment, and selected small molecule libraries. We combine our high throughput approach with detailed molecular studies to further our understanding of the mechanisms of disease and determine which compounds are most...

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Zon Laboratory

Dr. Leonard Zon's laboratory focuses on the developmental biology of hematopoiesis and cancer. Over the past five years, we have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. For instance, the isolation of the ferroportin iron transporter was based on a mutant zebrafish and subsequently was shown to be mutated in patients with iron overload disorders. The mutants also represent interesting key regulatory steps in the development of stem cells. Recently, a mutant was found that lacked blood stem cells...

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Rinn Laboratory

Our research aims to understand the role of long intergenic non-coding RNAs (lincRNAs) in establishing the distinct epigenetic states of adult and embryonic cells and their misregulation in diseases such as cancer. To further explore how lincRNAs may define and or drive cell fate decisions we developed computational methods to provide initial hypothesis of their functions. This “guilt by association method” pointed to a clear connection of lincRNAs and numerous cellular pathways ranging from pluripotency, cancer, adipogenesis to parasitology. We have employed systematic computational...

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