Aging and Stem Cells

Wagers Laboratory

Effective functioning of the body’s tissues and organs depends upon innate regenerative processes that maintain proper cell numbers (homeostasis) and replace damaged cells after injury (repair).  In many tissues, regenerative potential is determined by the presence and functionality of a dedicated population of stem and progenitor cells, which respond to exogenous cues to produce replacement cells when needed.  Understanding how these unspecialized precursors are maintained and regulated is essential for understanding the fundamental biology of tissues.  In addition, this...

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Lee Laboratory

Our goal is to understand heart failure and metabolic diseases that accompany human aging, as these diseases are now major barriers to healthy aging. We are interested in translating that understanding into therapies, including stem cell transplantation strategies and new biological agents.