Aging and Stem Cells

Rossi Laboratory

Hematopoietic stem cells (HSCs) are the only cells within the bone marrow that possess the ability to both differentiate to all blood lineages, and to self-renew for life. These properties, along with the remarkable ability of HSCs to engraft conditioned recipients upon intravenous transplantation, have established the clinical paradigm for stem cell use in regenerative medicine. However, despite the enormous clinical potential of HSCs, surprisingly little is known about the mechanisms that regulate their fundamental properties of self-renewal and multi-potency. Our lab has a...

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Wagers Laboratory

Effective functioning of the body’s tissues and organs depends upon innate regenerative processes that maintain proper cell numbers (homeostasis) and replace damaged cells after injury (repair).  In many tissues, regenerative potential is determined by the presence and functionality of a dedicated population of stem and progenitor cells, which respond to exogenous cues to produce replacement cells when needed.  Understanding how these unspecialized precursors are maintained and regulated is essential for understanding the fundamental biology of tissues.  In addition, this...

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Lee Laboratory

Our goal is to understand heart failure and metabolic diseases that accompany human aging, as these diseases are now major barriers to healthy aging. We are interested in translating that understanding into therapies, including stem cell transplantation strategies and new biological agents.