Yusuf RZ, Scadden DT. Fate through fat: lipid metabolism determines stem cell division outcome. Cell Metab. 2012 Oct 03; 16(4):411-3.

Citation

Yusuf RZ, Scadden DT. 2012. Fate through fat: lipid metabolism determines stem cell division outcome. Cell metabolism. 16(4):411-3. Pubmed: 23040066 DOI:S1550-4131(12)00371-3

Abstract

Distinctive metabolism associated with particular cell states is increasingly being defined in normal and malignant cells. Ito et al. (2012) now show that fatty acid oxidation is associated with hematopoietic stem cells and determines whether they undergo symmetric or asymmetric cell division, driving a fundamental property of the stem cell state.

Related Faculty

David Scadden, M.D.

Scadden Lab

David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.