What is the role of the bone marrow microenvironment in AML? Best Pract Res Clin Haematol. 2021 Dec; 34(4):101328.

Citation

Mulherkar N, Scadden DT. 2021. What is the role of the bone marrow microenvironment in AML?. Best practice & research. Clinical haematology. 34(4):101328. Pubmed: 34865700 DOI:S1521-6926(21)00093-1

Abstract

Acute myeloid leukemia (AML) continues to be associated with relapse and resistance to chemotherapy. The bone marrow microenvironment in AML has been shown to regulate responsiveness to chemotherapy and to support disease progression. This review summarizes some recent experimental insights into the crucial role of the bone marrow microenvironment in AML and persistence after chemotherapy.

Related Faculty

David Scadden, M.D.

Scadden Lab

David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.