Wang YH, Scadden DT. Targeting the Warburg effect for leukemia therapy: Magnitude matters. Mol Cell Oncol. 2015 Jul-Sep; 2(3):e981988.

Citation

Wang YH, Scadden DT. 2015. Targeting the Warburg effect for leukemia therapy: Magnitude matters. Molecular & cellular oncology. 2(3):e981988. Pubmed: 27308458 DOI:10.4161/23723556.2014.981988

Abstract

Non-oxidative glucose metabolism represents a hallmark of cancer. It is now apparent that different cell states among normal stem or progenitor cells have distinct aerobic glycolysis (AG) dependencies. However, malignant cells are markedly more vulnerable to modifications of AG regardless of the differentiation state of their cell of origin.

Related Faculty

David Scadden, M.D.

Scadden Lab

David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.