Non-oxidative glucose metabolism represents a hallmark of cancer. It is now apparent that different cell states among normal stem or progenitor cells have distinct aerobic glycolysis (AG) dependencies. However, malignant cells are markedly more vulnerable to modifications of AG regardless of the differentiation state of their cell of origin.

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David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.

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