Vujic A, Mahmoud AI, Lee RT. A Breakdown in Cooperativity Leads to Cardiac Identity Crisis. Cell. 2016 12 15; 167(7):1674-1676.

Citation

Vujic A, Mahmoud AI, Lee RT. 2016. A Breakdown in Cooperativity Leads to Cardiac Identity Crisis. Cell. 167(7):1674-1676. Pubmed: 27984717 DOI:S0092-8674(16)31671-3

Abstract

Using induced pluripotent stem cells, Ang et al. elucidate how a mutation in the transcription factor GATA4 causes congenital heart disease. They find that, although the recruitment of GATA4 to cardiac super-enhancers is retained, it no longer functions in partnership with another key transcription factor, leading to misexpression of non-cardiomyocyte genes.

Related Faculty

Richard Lee, M.D.

Lee Lab

Rich Lee seeks to understand heart failure and metabolic diseases that accompany human aging, and translate that understanding into therapies. Lee is an active clinician, regularly treating patients at Brigham and Women’s Hospital.