Vujic A, Bassaneze V, Lee RT. Genetic insights into mammalian heart regeneration. Nat Genet. 2017 Aug 30; 49(9):1292-1293.

Citation

Vujic A, Bassaneze V, Lee RT. 2017. Genetic insights into mammalian heart regeneration. Nature genetics. 49(9):1292-1293. Pubmed: 28854178 DOI:10.1038/ng.3942

Abstract

Genetic and functional analyses of 120 mouse strains have identified a heart regeneration candidate gene that modulates the contractile sarcomeric apparatus. This gene, Tnni3k, controls the frequency of the mononuclear, diploid cardiomyocyte population, which affects cardiomyocyte proliferative potential after injury.

Related Faculty

Richard Lee, M.D.

Lee Lab

Rich Lee seeks to understand heart failure and metabolic diseases that accompany human aging, and translate that understanding into therapies. Lee is an active clinician, regularly treating patients at Brigham and Women’s Hospital.