In this issue of Cell Stem Cell, Zaruba et al. (2009) describe a pharmacoregenerative strategy for myocardial infarction. Using G-CSF to release progenitors from bone marrow and protease inhibition to prevent degradation of the homing signal, SDF-1, the authors achieve increased recruitment to the heart and improved heart function.

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Rich Lee seeks to understand heart failure and metabolic diseases that accompany human aging, and translate that understanding into therapies. Lee is an active clinician, regularly treating patients at Brigham and Women’s Hospital.

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