Segers VF, Lee RT. 2007. Local delivery of proteins and the use of self-assembling peptides. Drug discovery today. 12(13-14):561-8. Pubmed: 17631251


Self-assembling peptides are members of a new class of molecules designed for tissue engineering and protein delivery. Upon injection in a physiological environment, self-assembling peptides form stable nanofiber hydrogels. Such biocompatible nanofibers can support three-dimensional growth and differentiation of many cell types. Self-assembling peptides are promising candidates for protein delivery, because they allow non-covalent binding of proteins, tethering of proteins, or incorporation of fusion proteins. Self-assembling peptides can be designed to deliver individual proteins or multiple factors, because the building blocks comprising self-assembling peptides can be designed with great flexibility.

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Rich Lee seeks to understand heart failure and metabolic diseases that accompany human aging, and translate that understanding into therapies. Lee is an active clinician, regularly treating patients at Brigham and Women’s Hospital.

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