Scadden DT, Fuller B, Cunningham JM. Human cells infected with retrovirus vectors acquire an endogenous murine provirus. J Virol. 1990 Jan; 64(1):424-7.

Citation

Scadden DT, Fuller B, Cunningham JM. 1990. Human cells infected with retrovirus vectors acquire an endogenous murine provirus. Journal of virology. 64(1):424-7. Pubmed: 2152828

Abstract

A 5.2-kilobase mouse RNA is expressed in human cells following infection with recombinant retroviruses propagated in mouse NIH 3T3 cells as psi-2 pseudotypes. This RNA is transcribed from a defective mink cell focus-forming provirus and copackaged into virions and integrated into human target cell DNA at a frequency comparable to that of the recombinant retrovirus genome.

Related Faculty

David Scadden, M.D.

Scadden Lab

David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.