Torres LS, Asada N, Weiss MJ, Trumpp A, Suda T, Scadden DT, Ito K. 2022. Recent advances in "sickle and niche" research - Tribute to Dr. Paul S Frenette. Stem cell reports. 17(7):1509-1535. Pubmed: 35830837 DOI:S2213-6711(22)00320-4


In this retrospective, we review the two research topics that formed the basis of the outstanding career of Dr. Paul S. Frenette. In the first part, we focus on sickle cell disease (SCD). The defining feature of SCD is polymerization of the deoxygenated mutant hemoglobin, which leads to a vicious cycle of hemolysis and vaso-occlusion. We survey important discoveries in SCD pathophysiology that have led to recent advances in treatment of SCD. The second part focuses on the hematopoietic stem cell (HSC) niche, the complex microenvironment within the bone marrow that controls HSC function and homeostasis. We detail the cells that constitute this niche, and the factors that these cells use to exert control over hematopoiesis. Here, we trace the scientific paths of Dr. Frenette, highlight key aspects of his research, and identify his most important scientific contributions in both fields.
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

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David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.

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