Raaijmakers MH, Scadden DT. Divided within: heterogeneity within adult stem cell pools. Cell. 2008 Dec 12; 135(6):1006-8.

Citation

Raaijmakers MH, Scadden DT. 2008. Divided within: heterogeneity within adult stem cell pools. Cell. 135(6):1006-8. Pubmed: 19070570 DOI:10.1016/j.cell.2008.11.034

Abstract

In this issue, Wilson et al. (2008) demonstrate that there are two functional subsets of hematopoietic stem cells that have distinctive kinetics of cell cycling. They present evidence that cells may transition between the two kinetic states, establishing one subpopulation that is ready to proliferate and another that is a deeply quiescent reserve.

Related Faculty

David Scadden, M.D.

Scadden Lab

David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.