McCarroll SA, Feng G, Hyman SE. Genome-scale neurogenetics: methodology and meaning. Nat Neurosci. 2014 Jun; 17(6):756-63.

Citation

McCarroll SA, Feng G, Hyman SE. 2014. Genome-scale neurogenetics: methodology and meaning. Nature neuroscience. 17(6):756-63. Pubmed: 24866041 DOI:10.1038/nn.3716

Abstract

Genetic analysis is currently offering glimpses into molecular mechanisms underlying such neuropsychiatric disorders as schizophrenia, bipolar disorder and autism. After years of frustration, success in identifying disease-associated DNA sequence variation has followed from new genomic technologies, new genome data resources, and global collaborations that could achieve the scale necessary to find the genes underlying highly polygenic disorders. Here we describe early results from genome-scale studies of large numbers of subjects and the emerging significance of these results for neurobiology.

Related Faculty

Steven Hyman, M.D.

Hyman Research

Steven Hyman is Director of the Stanley Center for Psychiatric Research at the Broad Institute, where his goal is to drive the genetics of schizophrenia to the point of diminishing returns with respect to biological information, with bipolar disorder following closely behind.