Lane AA, Scadden DT. Stem cells and DNA damage: persist or perish? Cell. 2010 Aug 06; 142(3):360-2.

Citation

Lane AA, Scadden DT. 2010. Stem cells and DNA damage: persist or perish?. Cell. 142(3):360-2. Pubmed: 20691895 DOI:10.1016/j.cell.2010.07.030

Abstract

Stem cells repopulate tissues after injury while also renewing themselves, but this makes them vulnerable to genotoxic damage. Mohrin et al. (2010) and Milyavsky et al. (2010) now show that mouse and human hematopoietic stem cells make opposing decisions about whether to die or to persist in response to DNA damage.

Related Faculty

David Scadden, M.D.

Scadden Lab

David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.