Krause DS, Scadden DT. Deconstructing the complexity of a microenvironmental niche. Cell. 2012 Mar 30; 149(1):16-7.

Citation

Krause DS, Scadden DT. 2012. Deconstructing the complexity of a microenvironmental niche. Cell. 149(1):16-7. Pubmed: 22464318 DOI:10.1016/j.cell.2012.03.005

Abstract

Cells acquire their fate in vivo in the context of a complex microenvironmental "niche" comprised of heterologous cell types, signaling molecules, extracellular matrix, biophysical forces, and metabolic substrates. Now Calderón and Boehm report the "refunctionalization" of a defective thymic epithelial niche, offering insights into how signaling molecules may be hierarchically organized to direct differentiation outcomes.

Related Faculty

David Scadden, M.D.

Scadden Lab

David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.