Kook SH, Cho JS, Morrison A, Wiener E, Lee SB, Scadden D, Lee BC. 2013. The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity. Cell death & disease. 4(7):e703. Pubmed: 23828566 DOI:10.1038/cddis.2013.218


In utero exposure of the embryo and fetus to radiation has been implicated in malformations or fetal death, and often produces lifelong health consequences such as cancers and mental retardation. Here we demonstrate that deletion of a G-protein-coupled purinergic receptor, P2Y14, confers potent resistance to in utero radiation. Intriguingly, a putative P2Y14 receptor ligand, UDP-glucose, phenocopies the effect of P2Y14 deficiency. These data indicate that P2Y14 is a receptor governing in utero tolerance to genotoxic stress that may be pharmacologically targeted to mitigate radiation toxicity in pregnancy.

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David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.

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