Citation

Hyman SE, Borsook D. 1996. Mechanisms regulating proenkephalin gene expression: contributions of transgenic models. NIDA research monograph. 161:59-71. Pubmed: 8784844

Abstract

This chapter gives an overview of the utility of one type of transgenic mouse model for substance abuse research, the use of transgenes in which genomic regulatory sequences of interest are coupled to a reporter gene. Using this mouse model, exploration of the mechanisms regulating expression of the proenkephalin gene in the mouse hypothalamus have begun. The resulting information supplements experiments on gene regulation performed in cell lines with information about regulation by pharmacologic and physiologic stimuli of interest within the brain. With special reference to mechanisms of opioid dependence, the particular model that has been examined appears to be a useful tool to investigate mechanistic aspects of the regulation of endogenous opioid genes by exogenous opioids.

Related Faculty

Photo of Steven Hyman

Steven Hyman is Director of the Stanley Center for Psychiatric Research at the Broad Institute and Chair of the Schizophrenia Spectrum Biomarkers Consortium (SSBC), a consortium identifying objective biomarkers to enable better diagnosis of and treatment for schizophrenia and related illnesses.

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