Hyman SE. A bone to pick with compulsive behavior. Cell. 2010 May 28; 141(5):752-4.

Citation

Hyman SE. 2010. A bone to pick with compulsive behavior. Cell. 141(5):752-4. Pubmed: 20510922 DOI:10.1016/j.cell.2010.05.010

Abstract

Mice with mutations in the Hoxb8 gene exhibit compulsive grooming behavior. Chen et al. (2010) now report that this behavior stems from Hoxb8 deficiency in microglia, a type of immune cell in the brain derived from bone marrow. These findings provide intriguing connections between immune dysfunction and neuropsychiatric disorders.

Related Faculty

Steven Hyman, M.D.

Hyman Research

Steven Hyman is Director of the Stanley Center for Psychiatric Research at the Broad Institute and Chair of the Schizophrenia Spectrum Biomarkers Consortium (SSBC), a consortium identifying objective biomarkers to enable better diagnosis of and treatment for schizophrenia and related illnesses.