Bjorkman PJ, et al. (1987) The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature.

Citation

Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC. 1967. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature. 329(6139):512-518. DOI:10.1038/329512a0

Abstract

Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens. Many residues critical for T-cell recognition of HLA are located in this site, in positions allowing them to serve as ligands to processed antigens. These findings have implications for how the products of the major histocompatibility complex (MHC) recognize foreign antigens. Article via http://europepmc.org/abstract/MED/2443855

Related Faculty

Jack Strominger, M.D.

Strominger Lab

Research Professor and Immunology pioneer Jack Strominger investigates self-tolerance and the immunology of pregnancy. His lab specializes in the structure and function of human histocompatibility proteins and their roles in disease.