Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC.
1937.
Structure of the human class I histocompatibility antigen, HLA-A2.
Nature.
329(6139):506-512.
DOI:10.1038/329506a0
The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by alpha-helices. A large groove between the alpha-helices provides a binding site for processed foreign antigens. An unknown 'antigen' is found in this site in crystals of purified HLA-A2.
Article via http://europepmc.org/abstract/MED/3309677
