Baryawno N, Severe N, Scadden DT. Hematopoiesis: Reconciling Historic Controversies about the Niche. Cell Stem Cell. 2017 05 04; 20(5):590-592.

Citation

Baryawno N, Severe N, Scadden DT. 2017. Hematopoiesis: Reconciling Historic Controversies about the Niche. Cell stem cell. 20(5):590-592. Pubmed: 28475884 DOI:S1934-5909(17)30124-8

Abstract

The niche, as first conceptualized, was in conflict with the prevailing wisdom that stem cells have internal logic. The niche hypothesis has been indisputably confirmed. Yet, recent findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors. Reconciling this conflict requires re-envisioning the niche as an enabler, not designer, of cell fate.

Related Faculty

David Scadden, M.D.

Scadden Lab

David Scadden’s laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer.