Artificial intelligence (AI) is rapidly transforming medical care, including in oncology, offering promising avenues for enhancing supportive care and symptom management. This review synthesizes current research on AI applications in this critical domain, exploring its potential to personalize interventions and improve patient-reported outcomes in oncology supportive care. We examine AI-driven tools for symptom monitoring, predictive analytics for adverse events, and personalized supportive care recommendations. Emphasis is placed on the integration of machine learning algorithms for real-time data analysis, enabling proactive interventions and timely symptom relief. We highlight challenges in translating AI-based solutions into clinical practice, including data privacy, algorithm bias, applicability for all patients, and the need for rigorous validation studies. Ultimately, the integration of AI in supportive oncology holds the potential to revolutionize patient-centered care, optimizing symptom control and improving the quality of life for individuals facing cancer. Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.