Ruiz i Altaba A, Melton DA. 1990. Axial patterning and the establishment of polarity in the frog embryo. Trends in genetics : TIG. 6(2):57-64. Pubmed: 2186530


We review the early development of the frog Xenopus laevis, concentrating on events that lead to the establishment of the body plan. Recent molecular and embryological experiments suggest that peptide growth factors and homeobox genes interact to specify cell fates and pattern during early development of this vertebrate.

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Doug Melton is pursuing a cure for type 1 diabetes. His lab studies the developmental biology of the pancreas, using that information to grow and develop pancreatic cells (islets of Langerhans). In parallel, they investigate ways to protect beta cells from autoimmune attack.

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