Mione M, Zon LI. Cancer and inflammation: an aspirin a day keeps the cancer at bay. Curr Biol. 2012 Jul 10; 22(13):R522-5.

Citation

Mione M, Zon LI. 2012. Cancer and inflammation: an aspirin a day keeps the cancer at bay. Current biology : CB. 22(13):R522-5. Pubmed: 22789999 DOI:10.1016/j.cub.2012.05.037

Abstract

Live imaging of the interactions between oncogene-transformed cells and leukocytes in zebrafish reveals that PGE(2) promotes the survival and proliferation of cancer cells. Non-steroid anti-inflammatory drugs, like aspirin, are the effective inhibitors of PGE(2) production and could be used with other anti-tumor agents in the treatment of cancer.

Related Faculty

Leonard Zon, M.D.

Zon Lab

The Zon laboratory aims to dissect how assaults to the hematopoietic system cause severe diseases such as leukemias, lymphomas, and anemias. They investigate hematopoietic development and disease using chemical screens, genetic screens, and analysis of novel transgenic lines in zebrafish.