McNeish J, Gardner JP, Wainger BJ, Woolf CJ, Eggan K. 2015. From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. Cell stem cell. 17(1):8-10. Pubmed: 26140603 DOI:S1934-5909(15)00273-8


While iPSCs have created unprecedented opportunities for drug discovery, there remains uncertainty concerning the path to the clinic for candidate therapeutics discovered with their use. Here we share lessons that we learned, and believe are generalizable to similar efforts, while taking a discovery made using iPSCs into a clinical trial.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Kevin Eggan investigates the mechanisms that cause motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS), and seeks to translate new discoveries into new therapeutic options for patients.

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