Ichida JK, Kiskinis E, Eggan K. 2010. Shushing down the epigenetic landscape towards stem cell differentiation. Development (Cambridge, England). 137(15):2455-60. Pubmed: 20554719 DOI:10.1242/dev.049130


In February 2010, researchers interested in stem cell biology gathered in Keystone, Colorado, USA to discuss their findings on the origins and behaviors of pluripotent and multipotent stem cells, and their therapeutic potential. Here, we review the presentations at that meeting and the questions that emerged concerning how a stem cell ;decides' to self-renew or differentiate, what their distinct properties are and how this information can be used to develop novel therapies.

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Kevin Eggan investigates the mechanisms that cause motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS), and seeks to translate new discoveries into new therapeutic options for patients.

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