de Boer AS, Eggan K. A perspective on stem cell modeling of amyotrophic lateral sclerosis. Cell Cycle. 2015; 14(23):3679-88.

Citation

de Boer AS, Eggan K. 2015. A perspective on stem cell modeling of amyotrophic lateral sclerosis. Cell cycle (Georgetown, Tex.). 14(23):3679-88. Pubmed: 26505672 DOI:10.1080/15384101.2015.1093712

Abstract

Amyotrophic lateral sclerosis is a complex neurodegenerative disease. Limitations in animal models have impeded progress in studying disease pathology and potential drug discovery. Here, we will review recent advances in the development of stem cell models for the study of ALS. Additionally, we will discuss the progress toward therapeutic development derived from these stem cell based assays.

Related Faculty

Kevin Eggan, Ph.D.

Eggan Lab

Kevin Eggan investigates the mechanisms that cause motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS), and seeks to translate new discoveries into new therapeutic options for patients.