Brunton SA, Stibbard JH, Rubin LL, Kruse LI, Guicherit OM, Boyd EA, Price S.2008.Potent inhibitors of the hedgehog signaling pathway.Journal of medicinal chemistry.51(5):1108-10.Pubmed: 18275133DOI:10.1021/jm070694n
Brunton SA, Stibbard JH, Rubin LL, Kruse LI, Guicherit OM, Boyd EA, Price S.2008.Potent inhibitors of the hedgehog signaling pathway.Journal of medicinal chemistry.51(5):1108-10.Pubmed: 18275133DOI:10.1021/jm070694n
A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
Abstract
A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
Lee Rubin investigates the key molecular mediators of different neurodegenerative diseases, with the ultimate goal of finding effective preclinical therapeutic candidates.
