Arlotta P. Organoids required! A new path to understanding human brain development and disease. Nat Methods. 2018 01 03; 15(1):27-29.

Citation

Arlotta P. 2018. Organoids required! A new path to understanding human brain development and disease. Nature methods. 15(1):27-29. Pubmed: 29298289 DOI:10.1038/nmeth.4557

Abstract

Our ability to study the developing human brain has recently been dramatically advanced by the development of human 'brain organoids', three-dimensional culture systems that recapitulate selected aspects of human brain development in reductionist, yet complex, tissues in vitro. Here I discuss the promises and challenges this new model system presents.

Related Faculty

Paola Arlotta, Ph.D.

Arlotta Lab

Dr. Arlotta is interested in understanding the molecular laws that govern the birth, differentiation and assembly of the cerebral cortex, the part of the brain that controls how we sense, move and think. She integrates developmental and evolutionary knowledge to investigate therapies for brain repair and for modeling neuropsychiatric disease.