Arlotta P, Hobert O. Homeotic Transformations of Neuronal Cell Identities. Trends Neurosci. 2015 Dec; 38(12):751-762.

Citation

Arlotta P, Hobert O. 2015. Homeotic Transformations of Neuronal Cell Identities. Trends in neurosciences. 38(12):751-762. Pubmed: 26596501 DOI:S0166-2236(15)00229-5

Abstract

Homeosis is classically defined as the transformation of one body part into something that resembles another body part. We propose here to broaden the concept of homeosis to the many neuronal cell identity transformations that have been uncovered over the past few years upon removal of specific regulatory factors in organisms from Caenorhabditis elegans to Drosophila, zebrafish, and mice. The concept of homeosis provides a framework for the evolution of cell type diversity in the brain.

Related Faculty

Paola Arlotta, Ph.D.

Arlotta Lab

Dr. Arlotta is interested in understanding the molecular laws that govern the birth, differentiation and assembly of the cerebral cortex, the part of the brain that controls how we sense, move and think. She integrates developmental and evolutionary knowledge to investigate therapies for brain repair and for modeling neuropsychiatric disease.