Epigenetics

Meissner Laboratory

Our laboratory is a mixed group of experimental and computational biologists in the Department of Stem Cell and Regenerative Biology (HSCRB).  We use genomic tools to study developmental and stem cell biology with a particular interest in the role of epigenetic regulation (Mikkelsen et al. Nature 2008; Koche, Smith et al. Cell Stem Cell 2011).

The term epigenetic refers to stable modifications of the chromatin and DNA that do not alter the primary nucleotide sequence. The global epigenetic makeup of a cell is a powerful indicator of its developmental state and potential. We...

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Zon Laboratory

Dr. Leonard Zon's laboratory focuses on the developmental biology of hematopoiesis and cancer. Over the past five years, we have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. For instance, the isolation of the ferroportin iron transporter was based on a mutant zebrafish and subsequently was shown to be mutated in patients with iron overload disorders. The mutants also represent interesting key regulatory steps in the development of stem cells. Recently, a mutant was found that lacked blood stem cells...

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