Cancer

Zon Laboratory

Dr. Leonard Zon's laboratory focuses on the developmental biology of hematopoiesis and cancer. Over the past five years, we have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. For instance, the isolation of the ferroportin iron transporter was based on a mutant zebrafish and subsequently was shown to be mutated in patients with iron overload disorders. The mutants also represent interesting key regulatory steps in the development of stem cells. Recently, a mutant was found that lacked blood stem cells...

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Verdine Laboratory

The research interests of the Verdine lab lie in the emerging area of chemical biology. We study biologic processes underlying growth and proliferation of human cancer cells, control of gene expression, and preservation of genomic integrity.

Our research has led to the invention of new and powerful approaches for the discovery of unconventional bioactive ligands termed "synthetic biologics" that have proven effective at addressing therapeutic targets previously considered "undruggable." Verdine and coworkers...

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