Dmitry Shvartsman

Dmitry Shvartsman

Senior Researcher
Dmitry Shvartsman

Dmitry Shvartsman

POSITION TITLE

 

Senior Researcher

 

EDUCATION/ TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

Tel Aviv University

B.Sc.

1998

Biology

Tel Aviv University

M.Sc.

2003

Neurobiochemistry

Tel Aviv University

Ph.D.

2008

Neurobiology

Harvard University

 

Postdoctoral

2008-2014

Biomedical Engineering

Brigham and Women’s Hospital in Boston/ Harvard Medical School

Research Fellow

2014-present

Nanomedicine and Biomaterials

         

 

Please complete the following sections:

  1. Personal Statement

My research is focused on understanding the biological mechanisms of tissue regeneration, stem cell biology, cell and drug delivery, and bioengineering. Currently I run a production team within Harvard Stem Cell Institute (HSCI) at Melton laboratory, focusing our effort on embryonic stem cell differentiation towards pancreatic lineages, with a particular interest on beta-cell biology and function. My broad interdisciplinary training and scientific background are combined with business development education, obtained through Harvard Business School courses and patent reviews for Harvard Office of Technological Development.

 

  1. Position and Honors
    1. 10/2011-08/2014               Research Associate, School of Engineering and Applied Sciences (SEAS), Harvard University
    2. 09/2014-05/2015               Research Fellow, Brigham and Women’s Hospital in Boston
    3. 07/2015-Present               Senior Researcher, Harvard Stem Cell Institute, Harvard University

Positions and emplyoment

1.    2004-2005                         Research Fellow, Felsenstein Research Medical Center (FMRC), Beilinson Medical Campus, Tel Aviv University

2.    2008-2011                         Young Investigator, School of Engineering and Applied Sciences (SEAS), Harvard University

Honors

  • ASME outstanding poster award, 06/2014, Boston, MA
  • European Molecular Biology Organization (EMBO) Long-Term Postdoctoral Fellowship(11/2008-11/2010)
  • Iafa Keydar Prize in Cancer Biology, Tel Aviv University, Israel (10/2007)
  • Constantiner Institute for Molecular Genetics Travel Scholarship, Tel Aviv University, Israel (9/2007)
  • Aharon Katzir Travel Scholarship for outstanding PhD students, Feinberg Graduate School, Weizmann institute for science (8/2007)
  • Trotzky foundation scholarship for excellent graduate students (06/2006)
  • Dean Scholarship for Excellency for Graduate Students (06/2007, 06/2004, 06/2003)

PUBLICATIONS

  1. Roche, E.T., Hastings, C.L., Lewin, S.A., Shvartsman, D.E., Brudno, Y., Vasilyev, N.V., O'Brien, F.J., Walsh, C.J., Duffy, G.P., and Mooney, D.J. Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart. Biomaterials 35, 6850-6858, (2014)
  2. Shvartsman, D., Storrie-White, H., Lee, K., Kearney, C., Brudno, Y., Ho, N., Cezar, C., McCann, C., Anderson, E., Koullias, J., et al. (2014). “Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles via NGF/GDNF Signaling.” Molecular therapy: the journal of the American Society of Gene Therapy, 22(7):1243-1253.
  3. Efrat Gottlieb-Abraham, Dmitry E. Shvartsman, John C. Donaldson, Marcelo Ehrlich, Orit Gutman, G. Steven Martin and Yoav I. Henis, “Src-mediated Caveolin-1 phosphorylation affects the targeting of active Src to specific membrane sites”, Mol. Biol. Cell 2013 24:24 3881-3895; 2013
  4. Ali OA, Tayalia P, Shvartsman D, Lewin S, & Mooney DJ “Inflammatory Cytokines Presented from Polymer Matrices Differentially Generate and Activate DCs In Situ”. Advanced Functional Materials 23(36): 4621-4628, 2013
  5. Yuen, W. W.; Du, N. R.; Shvartsman, D.; Arany, P. R.; Lam, H.; Mooney, D. J., “Statistical platform to discern spatial and temporal coordination of endothelial sprouting”,  Integrative Biology  2012, 4 (3), 292-300.
  6. Borselli, C., Cezar, C.A., Shvartsman, D., Vandenburgh, H.H. & Mooney, D.J. “The role of multifunctional delivery scaffold in the ability of cultured myoblasts to promote muscle regeneration”, Biomaterials 32, 8905-8914 (2011).
  7. Huebsch N., Arany P.R., Mao A.S., Shvartsman D., Ali O.A., Bencherif S.A., et al. “Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate”, Nature Materials. 2010;9(6):518-26.
  8. Kim J., Cao L., Shvartsman D., Silva E.A., Mooney D.J. “Targeted delivery of nanoparticles to ischemic muscle for imaging and therapeutic angiogenesis”, Nano Letters. 2011;11(2):694-700.
  9. Borselli C, Storrie H, Benesch-Lee F, Shvartsman D, Cezar C, Lichtman JW, et al. “Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors”, Proc Natl Acad Sci U S A. 2010;107(8):3287-92.
  10. Shvartsman D.E., Donaldson J.C., Diaz B., Gutman O., Martin G.S., Henis Y.I. “Src kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets” ,The Journal of Cell Biology. 2007;178(4):675-86.
  11. Levkovitz Y., Ben-Shushan G., Hershkovitz A., Isaac R., Gil-Ad I., Shvartsman D., et al. “Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases”,Molecular and Cellular Neuroscience. 2007;36(3):305-12
  12. Eisenberg S., Shvartsman D.E., Ehrlich M., Henis Y.I. “Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet H-Ras diffusion and signaling” Mol Cell Biol. 2006;26(19):7190-200.
  13. Shvartsman D.E., Gutman O., Tietz A., Henis Y.I. “Cyclodextrins but not compactin inhibit the lateral diffusion of membrane proteins independent of cholesterol” Traffic. 2006;7(7):917-26.
  14. Shvartsman D.E., Kotler M., Tall R.D., Roth M.G., Henis Y.I. “Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts”  The Journal of Cell Biology. 2003;163(4):879-88.
  15. Lachmanovich E., Shvartsman D.E., Malka Y., Botvin C., Henis Y.I., Weiss A.M. “Co-localization analysis of complex formation among membrane proteins by computerized fluorescence microscopy: application to immunofluorescence co-patching studies” J Microsc. 2003;212(2):122-31

Affiliation Status