Zhou Laboratory

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Research

This amazing transformation holds tremendous value for both fundamental biological understanding and regenerative medicine.  The ability to convert one cell to another provides powerful research tools to study the molecular and epigenetic mechanisms that govern cell identity and function in vivo. 

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Cells that gained new functions through reprogramming can be applied to treat injuries and degenerative diseases in situ.  We are currently focused on two major models: the reprogramming of diverse endodermal cell types into insulin-secreting beta cells, and the conversion of adult brain glial cells into a more juvenile form that strongly supports neuronal regeneration.  We collaborate extensively with bioengineers and clinicians to develop therapeutic strategies for diabetes, spinal cord injury, and stroke.